• MolecuVax, Inc. Announces Licensing of "Universal Cancer Vaccine" With Demonstrated Efficacy in Breast Cancer

    Clinical Stage Immunotherapy Company Expands Its Intellectual Property Portfolio by Exclusive Licensing of Issued Patents

    The patent covers vaccines that stimulate the immune system to selectively kill tumor cells that are expressing this universal "cancer specific" protein. In contrast to other vaccines, our vaccine is targeting BORIS protein that is critical for the growth of histologically different cancers. This possesses important implications in that if a cancer cell mutates to lose expression of the target, then the cancer cell will no longer be cancerous.

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  • MolecuVax, Inc. to Initiate Cancer Immunotherapy Clinical Trial

    Aimed at Eradicating Cancer Stem Cells Using MVAX-001

    BORIS represents a unique target in the fight against cancer because it is only found on cancer cells and not healthy tissues. Additionally, because it is selectively found on cancer stem cells, we possess the possibility of inducing an immune response that would strike cancer at its roots, which are the cancer stem cells.

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  • TSOI Licensing of Exosome Technology

    to MolecuVax, Inc.

    titled "Exosome Mediated Innate and Adaptive Immune Stimulation for Treatment of Cancer", a means of manufacturing exosomes that possess high concentrations of proteins found on tumors, which are specifically optimized to stimulate the immune system of cancer patients as a new form of immunotherapy.

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  • Immunotherapy:

    Using the Immune System to Treat Cancer

    The immune system’s natural capacity to detect and destroy abnormal cells may prevent the development of many cancers. However, cancer cells are sometimes able to avoid detection and destruction by the immune system.

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  • Immune Checkpoint Modulators

    Blocking the activity of immune checkpoint proteins

    releases the "brakes" on the immune system increasing its ability to destroy cancer cells. Several immune checkpoint inhibitors have been approved by the Food and Drug Administration (FDA).

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  • Immune Cell Therapy

    Progress is also being made with

    an experimental form of immunotherapy called adoptive cell transfer (ACT). In several small clinical trials testing ACT, some patients with very advanced cancer—primarily blood cancers—have had their disease completely eradicated. In some cases, these treatment responses have lasted for years.

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  • Therapeutic Antibodies

    are antibodies made in the laboratory

    that are designed to cause the destruction of cancer cells. One class of therapeutic antibodies, called antibody–drug conjugates (ADCs), has proven to be particularly effective, with several ADCs having been approved by the FDA for the treatment of different cancers.

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  • Cancer Treatment Vaccines

    are another approach to immunotherapy.

    These vaccines are usually made from a patient’s own tumor cells or from substances produced by tumor cells. They are designed to treat cancers that have already developed by strengthening the body’s natural defenses against the cancer.

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  • Immune System Modulators

    Yet another type of immunotherapy uses proteins

    that normally help regulate, or modulate, immune system activity to enhance the body’s immune response against cancer. These proteins include cytokines and certain growth factors. Two types of cytokines are used to treat patients with cancer: interleukins and interferons.

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  • CAR T-Cell Therapy

    Engineering Patients’ Immune Cells to Treat Their Cancers

    For years, the cornerstones of cancer treatment have been surgery, chemotherapy, and radiation therapy. Over the last decade, targeted therapies like imatinib (Gleevec®) and trastuzumab (Herceptin®)—drugs that target cancer cells by homing in on specific molecular changes seen primarily in those cells—have also emerged as standard treatments for a number of cancers.

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  • Understanding Precision Medicine in Cancer Treatment

    is an approach to patient care that allows doctors

    to select treatments that are most likely to help patients based on a genetic understanding of their disease. This may also be called personalized medicine. The idea of precision medicine is not new, but recent advances in science and technology have helped speed up the pace of this area of research.

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  • Cancer Statistics

    Cancer has a major impact on society in the United States and across the world.

    Cancer statistics describe what happens in large groups of people and provide a picture in time of the burden of cancer on society. Statistics tell us things such as how many people are diagnosed with and die from cancer each year, the number of people who are currently living after a cancer diagnosis, the average age at diagnosis, and the numbers of people who are still alive at a given time after diagnosis.

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  • Targeted Therapy

    is the foundation of precision medicine.

    It is a type of cancer treatment that targets the changes in cancer cells that help them grow, divide, and spread. As researchers learn more about the cell changes that drive cancer, they are better able to design promising therapies that target these changes or block their effects.

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  • Cancer Prevention

    Cancer prevention is action taken to lower the chance of getting cancer.

    In 2014, about 1.6 million people will be diagnosed with cancer in the United States. In addition to the physical problems and emotional distress caused by cancer, the high costs of care are also a burden to patients, their families, and to the public. By preventing cancer, the number of new cases of cancer is lowered.

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